Abstract
Enamel, the hardest and most mineralized tissue in the vertebrate body, is formed by ameloblast cells and is incapable of cell-mediated repair or remodelling. Because the circadian clock regulates a broad range of physiological processes, including that of other mineralized tissues influencing bone homeostasis and growth, the periodicity observed in enamel suggests that the molecular underpinnings orchestrating enamel development may be influenced by the circadian clock. Therefore, we wanted to study and investigate whether the microRNAs and their mRNA targets oscillate in a circadian pattern in developing molar tooth germ.
Enamel, the hardest and most mineralized tissue in the vertebrate body, is formed by ameloblast cells and is incapable of cell-mediated repair or remodelling. Because the circadian clock regulates a broad range of physiological processes, including that of other mineralized tissues influencing bone homeostasis and growth, the periodicity observed in enamel suggests that the molecular underpinnings orchestrating enamel development may be influenced by the circadian clock. Therefore, we wanted to study and investigate whether the microRNAs and their mRNA targets oscillate in a circadian pattern in developing molar tooth germ.