The tumor microenvironment and its assessment with DCE-MRI and DW-MRI
Metadata
Show metadataAppears in the following Collection
- Fysisk institutt [3626]
Abstract
Abnormal characteristics of the tumor microenvironment, such as hypoxia, high fluid pressure, and a dense extracellular matrix, significantly influence cancer progression and therapeutic response. Hence, to provide each patient with the optimal treatment, methods to non-invasively characterize the tumor microenvironment are needed. The current work explored the potential of two functional MRI methods – DCE-MRI and DW-MRI – to assess the microenvironment in solid tumors. In both cervical and pancreatic tumor xenografts, the DCE-MRI parameter Ktrans was strongly related to the fraction of hypoxic tissue. Moreover, the parameter ADC – derived from DW-MR images – was sensitive to the amount of extracellular collagen in cervical cancer xenografts. Therapy to modify the tumor vasculature has been proposed as a means to increase the supply of oxygen to tumors and enhance the effect of other cancer therapies. However, the present work demonstrates that so-called antiangiogenic therapy may increase the amount of hypoxia in cervical and pancreatic tumor xenografts. It was further revealed that DCE-MRI is a promising method to monitor the effect of antiangiogenic therapy on tumor oxygenation.List of papers
Paper I: Wegner C. S., Hauge A., Andersen L. K., Huang R., Simonsen T. G., Gaustad J., Rofstad E. K. Increasing aggressiveness of patient-derived xenograft models of cervix carcinoma during serial transplantation. Oncotarget. 2018; 9: 21036-21051. DOI: 10.18632/oncotarget.24783. The article is included in the thesis. Also available at: https://doi.org/10.18632/oncotarget.24783 |
Paper II: Hauge, A., Wegner, C.S., Gaustad, J. et al. DCE-MRI of patient-derived xenograft models of uterine cervix carcinoma: associations with parameters of the tumor microenvironment. J Transl Med 15, 225 (2017). DOI: 10.1186/s12967-017-1331-4. The article is included in the thesis. Also available at: https://doi.org/10.1186/s12967-017-1331-4 |
Paper III: Catherine S. Wegner, Anette Hauge, Jon-Vidar Gaustad, Lise Mari K. Andersen, Trude G. Simonsen, Kanthi Galappathi & Einar K. Rofstad (2017). Dynamic contrast-enhanced MRI of the microenvironment of pancreatic adenocarcinoma xenografts. Acta Oncologica, 56:12, 1754-1762, DOI: 10.1080/0284186X.2017.1343494. The article is not available in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1080/0284186X.2017.1343494 |
Paper IV: Hauge A., Wegner C. S., Gaustad J., Simonsen T. G., Andersen L. K., Rofstad E. K. Diffusion-weighted MRI-derived ADC values reflect collagen I content in PDX models of uterine cervical cancer. Oncotarget. 2017; 8: 105682-105691. DOI: 10.18632/oncotarget.22388. The article is included in the thesis. Also available at: https://doi.org/10.18632/oncotarget.22388 |
Paper V: Anette Hauge, Catherine S. Wegner, Jon-Vidar Gaustad, Trude G. Simonsen, Lise Mari K. Andersen, Einar K. Rofstad. Diffusion-Weighted MRI Is Insensitive to Changes in the Tumor Microenvironment Induced by Antiangiogenic Therapy. Translational Oncology, Volume 11(5), 2018, pp 1128-1136. DOI: 10.1016/j.tranon.2018.07.005. The article is included in the thesis. Also available at: https://doi.org/10.1016/j.tranon.2018.07.005 |
Paper VI: Catherine S. Wegner, Anette Hauge, Trude G. Simonsen, Jon-Vidar Gaustad, Lise Mari K. Andersen, Einar K. Rofstad. DCE-MRI of Sunitinib-Induced Changes in Tumor Microvasculature and Hypoxia: A Study of Pancreatic Ductal Adenocarcinoma Xenografts. Neoplasia, Volume 20(7), 2018, pp 734-744. DOI: 10.1016/j.neo.2018.05.006. The article is included in the thesis. Also available at: https://doi.org/10.1016/j.neo.2018.05.006 |
Paper VII: Anette Hauge, Jon-Vidar Gaustad, Ruixia Huang, Trude G. Simonsen, Catherine S. Wegner, Lise Mari K. Andersen, Einar K. Rofstad. DCE-MRI and Quantitative Histology Reveal Enhanced Vessel Maturation but Impaired Perfusion and Increased Hypoxia in Bevacizumab-Treated Cervical Carcinoma. International Journal of Radiation Oncology*Biology*Physics, Volume 104(3), 2019, pp 666-676. DOI: 10.1016/j.ijrobp.2019.03.002. The article is included in the thesis. Also available at: https://doi.org/10.1016/j.ijrobp.2019.03.002 |