High-intensity interval training in de novo heart transplant recipients with long-term follow-up
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- Institutt for klinisk medisin [10716]
Abstract
High-intensity interval training (HIT) is an effective method to increase VO2peak in maintenance heart transplant (HTx) recipients. There is limited evidence of HIT in the de novo HTx recipients, and the long-term effects of early initiation of HIT after HTx is unknown. The main aims of this thesis were to investigate the effects of HIT compared to moderate intensity continuous training (MICT) on VO2peak in de novo HTx recipients, with a 1-yr and a 3-yr follow-up. A secondary aim was to investigate pre-dictors for VO2peak in de novo HTx. At 1-yr follow-up there was a significantly higher mean change in VO2peak in the HIT group compared to the MICT group. The mean difference between groups was 1.8 mL/kg/min which is regarded as clinically meaningful. At 3-yrs follow-up, there was no longer a statistically significant mean difference between the groups in VO2peak. The mean difference between groups was still significant regarding muscular exercise capacity and the anaerobic threshold. HIT, performed decentralized instead of in the specialist health care setting, was found to be a safe and effective meth-od of exercise in this medically stable cohort of de novo HTx recipients, and showed also some sustainable long-term effects.List of papers
Paper 1: Rolid K, Andreassen AK, Yardley M, Bjørkelund E, Karason K, Wigh JP, Dall CH, Gustafsson F, Gullestad L, Nytrøen K. Clinical features and determinants of VO2peak in de novo heart transplant recipients. World J Transplant. 2018 Sep 10; 8(5):188-197. doi: 10.5500/wjt.v8.i5.188. The article is included in the thesis. Also available at: https://doi.org/10.5500/wjt.v8.i5.188 |
Paper 2: Nytrøen K, Rolid K, Andreassen AK, Yardley M, Gude E, Dahle DO, Bjørkelund E, Relbo Authen A, Grov I, Philip Wigh J, Have Dall C, Gustafsson F, Karason K, Gullestad L. Effect of High-Intensity Interval Training in De Novo Heart Transplant Recipients in Scandinavia. One-Year Follow-Up of the HITTS Randomized, Controlled Study. Circulation. 2019 May 7; 139(19):2198-2211. doi: 10.1161/CIRCULATIONAHA.118.036747. Erratum in: Circulation. 2019 Oct 22; 140(17):e737. The article is not available in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1161/CIRCULATIONAHA.118.036747 |
Paper 3: Rolid K, Andreassen AK, Yardley M, Gude E, Bjørkelund E, Authen AR, Grov I, Pettersen KI, Dall CH, Karason K, Broch K, Gullestad L, Nytrøen K. High-intensity interval training and health-related quality of life in de novo heart transplant recipients – results from a randomized controlled trial. Health Qual Life Outcomes. 2020 Aug 17; 18(1):283. doi: 10.1186/s12955-020-01536-4. The article is included in the thesis. Also available at: https://doi.org/10.1186/s12955-020-01536-4 |
Paper 4: Rolid K, Andreassen AK, Yardley M, Gude E, Bjørkelund E, Authen AR, Grov I, Broch K, Gullestad L, Nytrøen K. Long-term effects of high-intensity training vs moderate intensity training in heart transplant recipients: A 3-year follow-up study of the randomized-controlled HITTS study. Am J Transplant. 2020 Dec; 20(12):3538-3549. doi: 10.1111/ajt.16087. Epub 2020 Jun 28. The article is included in the thesis. Also available at: https://doi.org/10.1111/ajt.16087 |